HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride, 2,5-dimethyl- → 2,5-Dimethyl-N-(4-chloro-3-methyl-5-isoxazolyl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride, 2,5-dimethyl- | HCID 87910 | — |
| Reactant | 4-Chloro-3-methyl-1,2-oxazol-5-amine | HCID 10582822 | — |
| Product | 2,5-Dimethyl-N-(4-chloro-3-methyl-5-isoxazolyl)benzenesulfonamide | HCID 18617335 | 82% |
Reaction Steps
2,5-Dimethyl-N-(4-chloro-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-chloro-3-methylisoxazole and 2,5-dimethylbenzenesulfonyl chloride according to the procedures described in Example 25b. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a light yellow solid, m.p. 92-93° C., yield 82%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06376523B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-ba0705877c744ff29d8a743a40f6a872 |
| Source note | uspto-grants-2002_04 |