4-Nitrobenzenesulfonyl chloride → HCID 18617344, compound

HRID 842904Notes

Reaction equation

HRID 842904 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[N+:9]([C:12]1[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][CH:13]=1)([O-:11])=[O:10]>>[N+:9]([C:12]1[CH:13]=[CH:14][C:15]([S:18]([NH:1][C:2]2[O:6][N:5]=[C:4]([CH3:7])[C:3]=2[Br:8])(=[O:20])=[O:19])=[CH:16][CH:17]=1)([O-:11])=[O:10]

Participants

3

Reactant 2

HCID 74044-Nitrobenzenesulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 18617344HCID 18617344, compoundYield 34%

Procedure

4-Nitro-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 4-nitrobenzenesulfonyl chloride according to the procedures described in Example 30. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 146-149° C., yield 34%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give a crystalline solid, m.p. 146-149° C., yield 34%

Sources & evidence

ORD record
ord-8b18446ffa894228a520080769abe745
Source dataset
uspto-grants-2002_04
Patent number
US06376523B1

Reaction notes

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