Water → HCID 15480786, compound

Participants

Reaction Steps

To a solution of Compound 1a (6.2 g, 30 mmol) obtained in Step A in acetonitrile (94 mL) were added a 40% methanolic solution of Triton B (1.4 mL, 3.0 mmol) and methyl acrylate (27 mL, 300 mmol), followed by refluxing for 5 hours. The mixture was allowed to cool, and then poured into water, followed by extraction with ethyl acetate. The organic layer as washed with brine and dried over sodium sulfate, and the solvent was evaporated in vacuo. The residue was purified by silica gel column chromatography (eluted with hexane/ethyl acetate=2/1) to give Compound 1b (6.4 g, 56%) as a pale yellow oil.

Provenance & Evidence