Dimethyl Sulfoxide → HCID 15480788, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of Compound 1c (5.0 g, 15 mmol) obtained in Step C, DMSO(50 mL), water (5 mL), and sodium chloride (5.0 g) was stirred at 150° C. for 5 hours. The mixture was allowed to cool, and added water, followed by extraction with ethyl acetate. The organic layer was washed with brine and dried over sodium sulfate, and the solvent was evaporated in vacuo. The residue was purified by silica gel column chromatography (eluted with hexane/ethyl acetate=3/1) to give Compound 1 (3.6 g, 86%) as a white solid.

Provenance & Evidence