Hydrochloric Acid → HCID 12043737, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of Compound 10 (0.31 g, 0.87 mmol) obtained in Example 10 in ethanol (3.1 mL) and THF (3.1 mL) was added a 2 mol/L aqueous solution of sodium hydroxide (0.65 mL, 1.3 mmol), the mixture was stirred at 70° C. for 1 hour, and then a 2 mol/L aqueous solution of sodium hydroxide (0.65 mL, 1.3 mmol) was further added, followed by stirring at 70° C. for 1 hour. 1 mol/L hydrochloric acid was added dropwise under ice-cooling, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over sodium sulfate, the solvent was evaporated in vacuo, and the residue was triturated with ethanol to give Compound 11 (0.23 g, 82%) as a white solid.

Provenance & Evidence