Hydrochloric Acid → HCID 22616353, compound

Participants

Reaction Steps

To a solution of Compound 12a (9.0 g, 41 mmol) obtained in Step A in acetonitrile (135 mL) were added a 40% methanolic solution of Triton B (1.9 mL, 4.1 mmol) and methyl acrylate (37 mL , 410 mmol), and the mixture was stirred at room temperature for 30 minutes. Water and 1 mol/L hydrochloric acid were added, followed by extraction with ethyl acetate. The organic layer was washed with brine and dried over sodium sulfate, and the solvent was evaporated in vacuo. The residue was purified by silica gel column chromatography (eluted with hexane/ethyl acetate=5/2) to give Compound 12b (11 g, 68%) as a pale yellow oil.

Provenance & Evidence