Potassium Hydroxide → HCID 22616362, compound

Participants

Reaction Steps

To a mixture of diethyl 4-(8-methoxy-1,4-benzodioxan-5-yl)phthalate (0.69 g, 1.8 mmol) obtained by treating Compound A (0.70 g, 3.3 mmol) obtained in Reference Example 1 and known diethyl 4-bromophthalate (1.00 g, 3.3 mmol) by the same reaction as in Example 17 were added ethanol (7.0 mL) and a 6 mol/L aqueous solution of potassium hydroxide (1.4 mL), the mixture was stirred at room temperature for 2 hours, and then ethanol was evaporated in vacuo. Water was added to the resulting solution, the mixture was adjusted to pH 2 with 6 mol/L hydrochloric acid, and the precipitated solid was collected by filtration and dried in vacuo to give Compound B (0.55 g, 94%) as a white solid.

Provenance & Evidence