1-Butanol → HCID 18728491, compound

Participants

Reaction Steps

1 g (6.94 mmol) of cis-cyclobutane-1,2-dicarboxylic acid in 50 ml of n-butanol were heated under reflux with 0.3 g of conc. H2SO4 for 90 min. The mixture was then concentrated to about 5 ml and poured into dil. NaHCO3 solution, extracted with ethyl acetate, dried over sodium sulphate and concentrated. Purification was carried out chromatographically over silica gel (mobile phase: petroleum ether:ethyl acetate 100:2>100:5).

Provenance & Evidence