Triethylamine → HCID 22355046, compound

Participants

Reaction Steps

To a suspension of 4-amino phenylacetic acid (9 g, 60 mmol) and N-(benzyloxycarbonyloxy)-succinimide (15 g, 60 mmol) in CH2Cl2 was added enough triethylamine to form a homogeneous solution. The mixture was stirred at room temperature for 30 min and then CH2Cl2 was removed by rotavapor. The resulting residue was dissolved in water and acidified with 5% HCl. The solid thus formed was filtered and washed with 5% HCl, water, and diethyl ether to give 12 g (70%) of Cbz-aminophenylacetic acid as a brownish powder. 1H-NMR (300 MHz, DMSO-d6): 3.48 (s, 2H), 5.13 (s, 2H), 7.14 (d, 2H), 7.29-7.45 (m, 7H), 9.73 (s, 1 H).

Provenance & Evidence