Sodium Iodide → HCID 70169838, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N′-tert-butyl-N′-(3,5-dimethylbenzoyl)-N-(3-methoxy-2-methylbenzoyl)hydrazine carboxylic acid chloromethyl ester (15.0 g, 32.5 mmol) in 40 mL of acetone was added sodium iodide (9.8 g, 65.1 mmol)and heated to 30° C. for 3 h. The acetone was removed and the resulting slurry was treated with ether. The resulting white precipitated solids were filtered off, and the ether was then concentrated to afford yellow solids. Recrystallization from ether/hexanes afforded tannish crystals (20 g, 96%). 1H-NMR (300 MHz, CDCl3) δ (ppm): 1.64 (s, 9H), 1.97 (bs, 3H), 2.25 (s, 6H), 3.79 (s, 3H), 5.76 (s, 2H), 6,78-7.1 (m, 6H). Mp=70-72° C.

Provenance & Evidence