Hydrochloric Acid → HCID 54339358, compound

Participants

Reaction Steps

To a suspension of potassium carbonate (4.0 mg) and 4-[3-(tert-butoxycarbonyl-tert-butyl-amino)-propoxy]-3-hydroxymethyl-benzofuran-2-carboxylic acid (5.0 mg) in dry DMF (0.8 ml) was added methyl iodide (48 μl) at room temperature and the mixture was stirred overnight. The solvent was evaporated in vacuo to give the crude material as a white heavy syrup, which was then treated with 0.1N HCl (10 ml). The product was extracted with ethyl acetate (10 ml) three times and washed with saturated sodium hydrogen carbonate solution and dried over anhydrous sodium sulfate. The residue was purified by silica gel column chromatography developed by hexane-ethyl acetate to give 4-[3-(tert-butoxycarbonyl-tert-butyl-amino)-propoxy]-3-hydroxymethyl-benzofuran-2-carboxylic acid methyl ester (3.7 mg) as a white solid. FAB-MS: m/z 436 (MH+); 1H-NMR (CDCl3): δ 1.42-1.48 (18H, m), 2.11 (2H, quintet, J=7.3 Hz), 3.54 (2H, t, J=7.3 Hz), 4.07 (1H, t, J=6.9 Hz), 4.12 (2H, t, J=7.3 Hz), 4.48 (3H, s), 5.22 (2H, d, J=6.9 Hz), 6.68 (1H, d, J=7.9 Hz), 7.18 (1H, d, J=7.9 Hz), 7.40 (1H, dd, J=7.9 Hz, 7.9 Hz).

Provenance & Evidence