Sodium Cyanide → HCID 68655951, compound

Participants

Reaction Steps

The compound in Example 36 (12 mg, 0.022 mmol) and NaCN (1 mg) in saturated NH3 anhydrous MeOH solution was heated at 70° C. in a sealed flask overnight. Silica gel column chromatography (CH2Cl2/MeOH=20/1 to 10/1) gave desired product (10 mg, 88%) as a colorless solid. FAB-MS: m/z 486 (MH+); 1H-NMR (CD3OD): δ 2.01 (2H, m); 2.26 (3H, s), 2.80 (1H, t, J=6.9 Hz), 3.78 (2H, s), 4.10 (1H, t, J=5.9 Hz), 5.04 (2H, s), 5.80 (1H, brs), 6.50 (1H, brs), 6.52 (1H, d, J=7.6 Hz), 7.04-7.20 (5H, m), 7.33 (1H, d, J=8.9 Hz), 7.39 (1H, s), 8.41 (1H, brd, J=4.5 Hz), 8.49 (1H, brs).

Provenance & Evidence