m-Chloroperbenzoic acid → HCID 17927086, compound

Participants

Reaction Steps

To a solution of the compound in Example 56 (20 mg, 0.04 mmol) in CH2Cl2/TFA (8/2) (1 ml) was added m-CPBA (14 mg, 80%, 0.06 mmol) at 0° C. The mixture was stirred for 2 hours at room temperature. The solvent was removed under reduced pressure. The residue was purified over preparative TLC (CH2Cl2/MeOH=100/1) to give the desired compound (7.5 mg, 36%) as a colorless oil. FAB-MS: m/z 463 (MH+); 1H-NMR (CDCl3): δ 1.97 (2H, m), 2.24 (3H, s), 2.81 (2H, t, J=6.9 Hz), 2.88-3.07 (4H, m), 3.77 (2H, s), 4.04-4.10 (4H, m), 6.52 (1H, d, J=7.6 Hz), 6.91 (1H, d, J=7.6 Hz), 7.05-7.22 (7H, m), 7.58 (1H, d, J=7.8 Hz) 8.41 (1H, brd, J=4.5 Hz), 8.48 (1H, brs).

Provenance & Evidence