HCID 54146870, compound → HCID 54518313, compound

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Reaction Steps

2-{4-[3-(Benzyloxycarbonyl-tert-butyl-amino)-propoxy]-3-methyl-benzofuran-2-yl}-oxazole-4-carboxylic acid ethyl ester (20 mg) in methanol (5 ml) was treated with catalytic amount of 10% palladium on carbon under hydrogen atmosphere at room temperature for 18 hours. After filtration, evaporation and purification by silica gel column chromatography using 10:1 mixture of dichloromethane and methanol as an eluent, 2-{4-[3-(tert-butylamino)-propoxy]-3-methyl-benzofuran-2-yl}-oxazole-4-carboxylic acid ethyl ester was obtained as a white solid (8 mg). FAB-MS: m/z 401.

Provenance & Evidence