反应详情

(8-Bromo-octyl)-benzene (1 mmol) was added to a solution of 2-picoline (3 mmol) in acetonitrile, and the solution mixture was refluxed for 24 hours. The acetonitrile was removed in a vacuum, and the resulting residue was partitioned between ether and water. The aqueous layer was washed extensively with ether until no picoline was left in the aqueous layer. The resulting aqueous solution of the product was extracted with chloroform. The chloroform was removed to afford the product (70%). 1HNMR (300 MHz, CDCl3, ppm) 9.74 (d, 1H), 8.35 (m, 1H), 7.96 (m, 1H), 7.86 (d, 1H), 7.15-7.25 (m, 4H), 4.92 (t, 2H), 2.95 (s, 3H), 1.88-1.98 (m, 2H), 1.54-1.64 (m, 2H), 1.39-1.49 (m, 2H), 1.25-1.38 (br, 6H).

1. temperaturethe solution mixture was refluxed for 24 hours
2. customThe acetonitrile was removed in a vacuum
3. customthe resulting residue was partitioned between ether and water
4. washThe aqueous layer was washed extensively with ether until no picoline
5. waitwas left in the aqueous layer
6. extractionThe resulting aqueous solution of the product was extracted with chloroform
7. customThe chloroform was removed