Potassium Carbonate → HCID 53884645, compound

Participants

Reaction Steps

4-Hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester (100 mg), potassium carbonate (500 mg) and 2-iodoethanol (195 μl) were suspended in acetonitrile (10 ml). The mixture was refluxed overnight. Inorganic salt was filtered out and the mother solution was evaporated to dryness. The residue was dissolved in ethyl acetate, washed with water, dried over anhydrous sodium sulfate and evaporated to dryness. The residue was purified by silica gel column chromatography developed by ethyl acetate-hexane to give 4-(2-hydroxy-ethoxy)-3-methyl-benzofuran-2-carboxylic acid ethyl ester (77 mg) as a white powder. FAB-MS: m/z 265 (MH+).

Provenance & Evidence