HCID 53876405, compound → HCID 500951, compound

Participants

Reaction Steps

To a solution of {3-[2-(hydroxy-pyridin-2-yl-methyl)-3-methyl-benzofuran-4-yloxy]-propyl}-pyridin-3-ylmethyl-carbamic acid tert-butyl ester (30 mg) in chloroform (2 ml) was added manganese(IV) oxide (45 mg) at room temperature and the mixture was stirred vigorously overnight. The mixture was filtered through a pad of Celite and concentrated in vacuo. The titled compound (24 mg) was obtained as a pale yellow oil after the purification with silica gel TLC developed by the mixture of dichlormethane and methanol. FAB-MS: m/z 502 (MH+); 1H-NMR (CDCl3): δ 1.45 (9H, s), 2.10-2.15 (2H, m), 2.91 (3H, s), 3.40-3.50 (2H, m), 4.09 (2H, t, J=5.9 Hz), 4.48 (2H, broad s), 6.58 (1H, d, J=8.3 Hz), 7.10 (1H, d, J=8.3 Hz), 7.24 (1H, dd, J=5.3 Hz, 7.6 Hz), 7.34 (1H, t, J=8.3 Hz), 7.47-7.55 (2H, m), 7.87-7.98 (2H, m), 8.50-8.53 (2H, m), 8.77-8.80 (1H, m).

Provenance & Evidence