3-Nitrophenylhydrazinium(1+) chloride → HCID 69922815, compound

HRID 843183Notes

Reaction equation

HRID 843183 reaction equation
C(OC([N:8]([CH2:26][C:27]1[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=1)[CH2:9][CH2:10][CH2:11][O:12][C:13]1[C:18]2[C:19]([CH3:25])=[C:20]([C:22]([OH:24])=O)[O:21][C:17]=2[CH:16]=[CH:15][CH:14]=1)=O)(C)(C)C.Cl.[N+:34]([C:37]1[CH:38]=[C:39]([NH:43][NH2:44])[CH:40]=[CH:41][CH:42]=1)([O-:36])=[O:35]>>[N+:34]([C:37]1[CH:38]=[C:39]([NH:43][NH:44][C:22]([C:20]2[O:21][C:17]3[CH:16]=[CH:15][CH:14]=[C:13]([O:12][CH2:11][CH2:10][CH2:9][NH:8][CH2:26][C:27]4[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=4)[C:18]=3[C:19]=2[CH3:25])=[O:24])[CH:40]=[CH:41][CH:42]=1)([O-:36])=[O:35]

Participants

3

Reactant 2

HCID 54642853-Nitrophenylhydrazinium(1+) chlorideHCID 22615024HCID 22615024, compound

Product 1

HCID 69922815HCID 69922815, compound

Procedure

This compound was prepared from 4-[3-(tert-butoxycarbonyl-pyridin-3-ylmethyl-amino)-propoxy]-3-methyl-benzofuran-2-carboxylic acid (Example 139-a) and 3-nitrophenylhydrazine hydrochloride in a similar manner to Example 139-b and 139-c. ESI-MS: m/z 476 (MH+), 1H-NMR δ: 2.07 (2H, tt, J=5.9, 6.8 Hz), 2.69 (3H, s), 2.88 (2H, t, J=6.8 Hz), 3.84 (2H, s), 4.18 (2H, t, J=5.9 Hz), 6.51 (1H, m), 6.66 (1H, d, J=7.9 Hz), 7.07 (1H, d, J=7.9 Hz), 7.20-7.42 (4H, m), 7.67 (1H, m), 7.74-7.77 (2H, m), 8.41 (1H, m), 8.49 (1H, m), 8.56 (1H, m).

Sources & evidence

ORD record
ord-9f4afcde4bef4a2ebc4a252a87cd2c25
Source dataset
uspto-grants-2002_04
Patent number
US06376491B1

Reaction notes

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