Tetrahydrofuran → HCID 22616785, compound

Participants

Reaction Steps

To a solution containing sodium malonate (17.0 g) of Example 7 in dry tetrahydrofuran (100 g), bicyclo[3,2,2]non-8-ene-2-carboxaldehyde (15 g) obtained in Preparation Example 6 is slowly added, and the reaction is carried out at −20° C. in a nitrogen atmosphere for 1 hour, and then at 50° C. for 10 hours. Then, the reaction mixture is worked up as in the procedure of Example 1, to obtain 24 g of the pure title compound (purity: 99%, yield: 90%).

Provenance & Evidence