HCID 68807570, compound → HCID 69504664, compound

HRID 843207Notes

Reaction equation

HRID 843207 reaction equation
[OH:1][C@H:2]1[CH2:24][CH2:23][C@@:22]2([CH3:25])[C:4](=[CH:5][CH2:6][C@@H:7]3[C@@H:21]2[CH2:20][C@@H:19]([OH:26])[C@@:18]2([CH3:27])[C@:8]3([OH:28])[CH2:9][CH2:10][C@@H:11]2[C:12]2(OCCO2)[CH3:13])[CH2:3]1>C(O)(=O)C>[OH:1][C@H:2]1[CH2:24][CH2:23][C@@:22]2([CH3:25])[C:4](=[CH:5][CH2:6][C@@H:7]3[C@@H:21]2[CH2:20][C@@H:19]([OH:26])[C@@:18]2([CH3:27])[C@:8]3([OH:28])[CH2:9][CH2:10][C@@H:11]2[CH2:12][CH3:13])[CH2:3]1

Participants

3

Reactant 1

HCID 68807570HCID 68807570, compound

Product 1

HCID 69504664HCID 69504664, compoundYield 93.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The ethylenedioxypregnene (25) (250 mg, 0,64 mmol) is dissolved in acetic acid (13,4 ml) and water which after freeze drying affords the trihydroxy steroid (15) (200 mg, 89%), m.p.: 228°-235° C. (lit 225°-235° C.), M+ 348, [αD]20+35° (lit [αD]20+29°).

Workup

  1. dry with materialwater which after freeze drying

Sources & evidence

ORD record
ord-a73928f4ff50454aa137df532c1d4b26
Source dataset
uspto-grants-2002_04
Patent number
US06376657B1

Reaction notes

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