Ethyl bromoacetate → HCID 22616837, compound

Participants

Reaction Conditions

Reaction Steps

7.7 g (0.034 mol) of 4-(4-cyanophenylazo)phenol, 8.52 g (0.051 mol) ethyl bromoacetate (Fluka, pract.) and 5.66 g (0.041 mol) of dried K2CO3 were mixed in a 250 mL one-neck round flask fitted with a magnetic stirring bar. 100 mL of dry acetone was added, the flask was closed with a reflux condenser protected on the top with a CaCl2-drying tube and the stirred solution was refluxed on an oil bath at 60° C. for 72 h After cooling the flask was transferred to a Rotavapor and the acetone is removed by rotary evaporation. The resulting solid mixture was added 100 mL of 30° C. water and filtered. The filtercake was mixed with 50 mL of cold ethanol. After filtration and vacuum drying 9.19 g (yield 87%) of ethyl 2-[4-(4-cyanophenylazo)-phenoxy]-ethanoate was recovered.

Provenance & Evidence