Acetonitrile → HCID 9882847, compound

HRID 843275Notes

Reaction equation

HRID 843275 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]2[CH:19]=[C:18]([C:20]([OH:22])=[O:21])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)=[CH:2]1.[C:23](#N)C.[N+](=C)=[N-]>CCOCC>[CH3:23][O:21][C:20]([C:18]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=2)[CH:19]=1)=[O:22]

Participants

5

Reactant 3

HCID 6342AcetonitrileHCID 9550DiazomethaneHCID 226169942-(1H-Indol-3-yl)quinoline-4-carboxylic acid

Product 1

HCID 9882847HCID 9882847, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a 10 mL pear-shaped flask was added 2-(3-indolyl)-4-quinolinecarboxylic acid (1 mmol) and 2 mL of acetonitrile followed by a solution of diazomethane (5 mmol) in 2 mL of ether. The reaction mixture was stirred for 1 h and the solvent removed in vacuo to give methyl-2-(3-indolyl)-4-quinolinecarboxylate (95-100% yield).

Workup

  1. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-7799f479f0644314b9b7b561adabfb1e
Source dataset
uspto-grants-2002_04
Patent number
US06376670B1

Reaction notes

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