Benzylamine → HCID 22617109, compound

HRID 843296Notes

Reaction equation

HRID 843296 reaction equation
C(O[C:5]([O:12][CH2:13][CH2:14][CH3:15])=[N:6][NH:7][C:8]([O:10]C)=O)CC.[CH2:16]([NH2:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CO>[CH2:16]([N:23]1[C:5]([O:12][CH2:13][CH2:14][CH3:15])=[N:6][NH:7][C:8]1=[O:10])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 22617107HCID 22617107, compound

Product 1

HCID 22617109HCID 22617109, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In an autoclave, 2.04 g of methyl N′-dipropoxymethylenehydrazinecarboxylate (8.9 mmol) and 3.46 g of benzylamine (31.6 mmol) were initially charged in 25.8 g of methanol. After 5 hours at 110° C., the solvent was distilled off and the 4-methyl-5-propoxy-2,4-dihydro-1,2,4-triazol-3one was recrystallized from ethyl acetate. This gave 0.57 g (27%) of pure 4-benzyl-5-propoxy-2,4-dihydro-l,2,4-triazol-3-one.

Workup

  1. distillationthe solvent was distilled off
  2. customthe 4-methyl-5-propoxy-2,4-dihydro-1,2,4-triazol-3one was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-84df76d684bd487ba25f40d9f82aed46
Source dataset
uspto-grants-2002_04
Patent number
US06376699B1

Reaction notes

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