Methanol → 4-(Trifluoromethyl)benzylamine

The second step of the process of the present invention was conducted as follows. At first, a 100 ml autoclave equipped with an electromagnetic stirrer was charged with 5.00 g (26 mmol) of 4-trifluoromethylbenzaldehyde oxime, 50 ml of 2M-ammoniacal methanol solution (containing 100 mmol of ammonia), and 0.25 g of a catalyst (i.e., a carbon powder (50% wet) carrying thereon 5% palladium), followed by introduction of hydrogen to have an inside pressure of 1 MPa. Then, the reaction mixture was stirred, while the reaction temperature was maintained at 20° C. and while hydrogen was gradually introduced into the autoclave in a manner to maintain the total pressure at 1 MPa. After conducting the reaction for 2 hr, the reaction was stopped, followed by removing the catalyst by filtration. As a result of analyzing the obtained reaction liquid by gas chromatography, 4-trifluoromethylbenzylamine was formed at a yield of 87.6%.

1. customAt first, a 100 ml autoclave equipped with an electromagnetic stirrer
2. additionwas gradually introduced into the autoclave in a manner
3. temperatureto maintain the total pressure at 1 MPa
4. customthe reaction for 2 hr
5. customby removing the catalyst
6. filtrationby filtration
7. customAs a result
8. customthe obtained reaction liquid by gas chromatography

ORD record

ord-e5017f760b794e7ea964776e4806aeba

Source dataset

uspto-grants-2002_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06376712B2