Dimethylformamide → HCID 131723196, compound

Participants

Reaction Steps

To a solution of 2-amino-N-benzyloxy-(R)-propionamide HCl Salt (200 mg, 0.868 mmol) and (R,S)-2-phenylbutyric acid (143 mg, 0.868 mmol) in 3 mL DMF cooled in an ice bath was added BOP (384 mg, 0.868 mmol) followed by DIEA (0.7 mL, 4 mmol). After stirring for 1 hour at room temperature, the solution was diluted with EtOAC, washed with NaHCO3 and brine, dried over MgSO4, and concentrated. Purification on a silica gel column using 5% MeOH in CH2Cl2 gave the amide product (260 mg, 88%) as a solid. MS (ESI): (M−H)−=339.1.

Provenance & Evidence