Ibuprofen, (+-)- → HCID 88035684, compound

HRID 843390Notes

Reaction equation

Cl.[NH2:2][C@H:3]([CH3:15])[C:4]([NH:6][O:7]CC1C=CC=CC=1)=[O:5].[CH3:16][CH:17]([C:21]1[CH:26]=[CH:25][C:24]([CH2:27][CH:28]([CH3:30])[CH3:29])=[CH:23][CH:22]=1)[C:18]([OH:20])=O>>[CH3:16][CH:17]([C:21]1[CH:26]=[CH:25][C:24]([CH2:27][CH:28]([CH3:30])[CH3:29])=[CH:23][CH:22]=1)[C:18]([NH:2][C@H:3]([CH3:15])[C:4]([NH:6][OH:7])=[O:5])=[O:20]

Participants

Reactant 2

HCID 3672Ibuprofen, (+-)-

HCID 88035642HCID 88035642, compound

Product 1

HCID 88035684HCID 88035684, compound

Procedure

This compound was synthesized by coupling 2-amino-N-benzyloxy-(R)-propionamide HCl salt 42b with (R/S)-α-methyl-4-isobutylphenylacetic acid followed by hydrogenation using the procedures as described in Example 42. MS (ESI): (M−H)−=291.0.

Workup

customThis compound was synthesized

Sources & evidence

ORD record: ord-2a2b676cee9043d6915213223b60be63
Source dataset: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06376665B1

Reaction notes

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