HCID 69883297, compound → HCID 69883181, compound

Participants

Reaction Steps

A solution of methyl 2-[N-methyl-N-((R/S)-α-t-butoxycarbonylmethyl-4-benzyloxyphenylacetyl)amino]-(R)-propionate 48c (3.0 g, 6.59 mmol) in MeOH (75 mL) was hydrogenated under atmospheric pressure using 10% Pd/C (0.6 g) as a catalyst for a period of 4.5 hours. The catalyst was filtered off and the solvent was removed under reduced pressure. The residue was purified on a silica gel column using 40% EtOAc/hexane as an eluent to afford the phenol product (1.5 g, 62%) as a solid. MS (CI—NH3): (M+H)+=366.

Provenance & Evidence