HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylstannane → 4-Benzoyloxy-1-(2-hydroxycyclohexyloxy)-2,2,6,6-tetramethylpiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylstannane | HCID 5948 | — |
| Reactant | Heptane | HCID 8900 | — |
| Reactant | 2-Bromocyclohexanol | HCID 266411 | — |
| Reactant | 1-Hydroxy-4-benzoyloxy-2,2,6,6-tetramethylpiperidine | HCID 688178 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | 4-Benzoyloxy-1-(2-hydroxycyclohexyloxy)-2,2,6,6-tetramethylpiperidine | HCID 22507645 | — |
Reaction Steps
Tributyltin hydride is added dropwise to a solution of 2-bromocyclohexanol and excess 4-benzoyloxy-1-oxyl-2,2,6,6-tetramethylpiperidine in chlorobenzene. The mixture is heated to facilitate reaction. The crude reaction mixture is passed through silica gel with heptane and then heptane/ethyl acetate to afford the title compound as a mixture of cis/trans isomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06376584B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-dea195a2f22a4c0c902aa4d5569c65d2 |
| Source note | uspto-grants-2002_04 |