Morpholine → 4-(4-Nitrophenyl)morpholine

HRID 843489Notes

Reaction equation

HRID 843489 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[CH:3][CH:4]=1)([O-:10])=[O:9]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 9590p-Fluoronitrobenzene

Product 1

HCID 252224-(4-Nitrophenyl)morpholine

Procedure

1-Fluoro-4-nitrobenzene (10 g, 70.9 mmoles) is refluxed for 5 hours with 35.7 g (0.41 moles) of morpholine. After that, the reaction product is poured onto 400 g of ice/water and the solid obtained is filtered off. After a recrystallization from ethanol, a dark yellow, finely pulverized dye is obtained with a melting point of 152°-154° C.

Workup

  1. customthe solid obtained
  2. filtrationis filtered off
  3. customAfter a recrystallization from ethanol
  4. customa dark yellow, finely pulverized dye is obtained with a melting point of 152°-154° C.

Sources & evidence

ORD record
ord-4adb4224f154439bba031b3b7ef964f8
Source dataset
uspto-grants-2002_04
Patent number
US06379400B1

Reaction notes

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