反应详情

A solution of bisbenzimidazole (6 g; 0.01 mol) dicyclohexylcarbodiimide (0.05 mol) and Succinic acid (0.01 mol) in 100 mL chloroform is stirred overnight for 18-24 hrs. During this time, a white precipitate is formed. The precipitate is filtered and washed with chloroform (2×50 mL). The chloroform washes are combined and concentrated under vacuum in a rotary evaporator and the residue purified by flash column chromatography. The fractions containing the product are combined and concentrated under vacuum in a rotary evaporate to afford bisbenzimide succinnate ester (80%) as a white solid.

1. customDuring this time, a white precipitate is formed
2. filtrationThe precipitate is filtered
3. washwashed with chloroform (2×50 mL)
4. concentrationconcentrated under vacuum in a rotary evaporator
5. customthe residue purified by flash column chromatography
6. additionThe fractions containing the product
7. concentrationconcentrated under vacuum in
8. customa rotary evaporate