反应详情

温度

65 °C

A mixture of 4-(5-bromopentyl)-1,1′-biphenyl (360 mg, 1.19 mmol) and 4-n-butylpyridine (0.5 mL) was heated at 60-70° C. for 12 hrs. The resulting mixture was washed with diethyl ether and then dissolved in water (15 mL). The aqueous solution was extracted with ethyl acetate (30 mL×3). Water was removed by lyophilization to afford 377 mg of the title compound. Yield: 72%. 1H NMR (300 MHz, CDCl3) δ 0.92 (t, J=7.2 Hz, 3H), 1.29-1.53 (m, 4H), 1.60-1.80 (m, 4H), 2.08 (m, 2H), 2.63 (t, J=7.5 Hz, 2H), 2.85 (t, J=7.8 Hz, 2H), 4.94 (t, J=7.5 Hz, 2H), 7.18-7.60 (m, 9H), 8.00 (t, J=7.2 Hz, 1H), 8.16 (d, J=8.1 Hz, 1H), 9.29 (d, J=6.0 Hz, 1H), 9.30 (s, 1H) ppm; 13C NMR (75 MHz, CDCl3) δ 13.9, 22.3, 25.7, 30.8, 32.0, 32.5, 32.6, 35.2, 61.7, 126.8, 127.0, 127.1, 128.0, 128.8, 128.9, 138.6, 140.8, 141.1, 142.5, 144.0, 144.1, 144.6 ppm.

1. washThe resulting mixture was washed with diethyl ether
2. dissolutiondissolved in water (15 mL)
3. extractionThe aqueous solution was extracted with ethyl acetate (30 mL×3)
4. customWater was removed by lyophilization