反应详情

A mixture of the protected glycerol derivative 14 (5.0 g, 16 mmol) and 10% palladium on activated carbon (wet Degussa type E101 NE/W) (0.43 g) in MeOH (50 mL) was evacuated using an aspirator pump and filled with hydrogen. After 2 h, TLC analysis showed the reaction to be complete, the mixture was filtered through Celite and the filtrate was evaporated to dryness to give 1-O-t-butyldimethylsilyl-2-O-methyl-rac-glycerol (15) (99%) as a colourless oil.

1. customwas evacuated
2. additionfilled with hydrogen
3. customthe reaction
4. filtrationthe mixture was filtered through Celite
5. customthe filtrate was evaporated to dryness