反应详情

To a solution of alcohol 15 (1.1 g, 5.0 mmol) in CH2Cl2 (10 mL) was added oleoyl chloride (1.8 mL, 5.5 mmol) followed, after 5 min, by the addition of pyridine (0.44 mL, 5.5 mmol). After TLC analysis indicated that the reaction had gone to completion, the mixture was partitioned between ethyl acetate (100 mL) and H2O (30 mL), the organic extract was dried (MgSO4) and concentrated to give 1-O-t-butyldimethylsilyl-2-O-methyl-3-O-oleoyl-rac-glycerol (16) (2.4 g, 99%) as a dark brown oil.

1. customthe mixture was partitioned between ethyl acetate (100 mL) and H2O (30 mL)
2. extractionthe organic extract
3. dry with materialwas dried (MgSO4)
4. concentrationconcentrated