反应详情

温度

65 °C

A mixture of 4-(5-bromopentyl)-1,1′-biphenyl (335 mg, 1.10 mmol) and pyridine (1 mL) was heated at 60-70° C. for 12 hrs. The resulted mixture was washed with diethyl ether and then dissolved in water (15 mL). The aqueous solution was extracted with diethyl ether (30 mL×3). Water was removed by lyophilization to afford 381 mg of the title compound. Yield: 90%. 1H NMR (300 MHz, CDCl3) δ 1.44 (m, 2H), 1.69 (m, 2H), 2.07 (m, 2H), 2.62 (t, J=7.5 Hz, 2H), 4.96 (t, J=7.5 Hz, 2H), 7.15-7.60 (m, 9H), 8.06 (t, J=6.9 Hz, 2H), 8.42 (d, J=7.8 Hz, 1H), 9.48 (d, J=6.0 Hz, 2H) ppm; 13C NMR (75 MHz, CDCl3) δ 25.6, 30.7, 31.9, 35.2, 61.8, 126.8, 127.0, 127.1, 128.4, 128.8, 128.9, 138.6, 140.8, 141.0, 145.0 ppm.

1. washThe resulted mixture was washed with diethyl ether
2. dissolutiondissolved in water (15 mL)
3. extractionThe aqueous solution was extracted with diethyl ether (30 mL×3)
4. customWater was removed by lyophilization