HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-(1,3-Dioxan-2-yl)-1-methyl-1H-imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,3-Propanediol | HCID 10442 | — |
| Reactant | Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- | HCID 18462 | — |
| Reactant | 1-methyl-1H-imidazole-5-carbaldehyde | HCID 573592 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(1,3-Dioxan-2-yl)-1-methyl-1H-imidazole | HCID 57919632 | — |
Reaction Steps
To a solution of 1-methyl-1H-imidazole-5-carbaldehyde (2.9 g, 26.3 mmol) in toluene (20 mL) was added propane-1,3-diol (4.01 g, 52.7 mmol) and CSA (0.306 g, 1.317 mmol) and the reaction mixture was heated to reflux with azeotropic removal of the evolved water for 24 hours. The reaction mixture was cooled to RT, diluted with DCM and washed with NaHCO3 solution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846927B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-e7428bd3e70b498dbb8013ec465cb6e1 |
| Source note | uspto-grants-2014_09 |