反应详情

To a solution of 2-(3′-nitrophenyl)-5-(p-tolyl)-1,3,4-thiadiazole (0.66 g, 2.22 mmol) in CCl4 (75 ml) is added NBS (0.43 g, 2.44 mmol) and refluxed for 12 hours. The mixture is then concentrated and the residue is taken up In chloroform (50 ml) and washed with saturated NaHCO3 (50 ml) and brine (50 ml). The organic layer is dried over MgSO4 and concentrated to yield 2-(3′-nitrophenyl)-5-(p-bromomethylphenyl)-1,3,4-thiadiazole as a tan solid. (0.69 g, 83%).

1. temperaturerefluxed for 12 hours
2. concentrationThe mixture is then concentrated
3. washwashed with saturated NaHCO3 (50 ml) and brine (50 ml)
4. dry with materialThe organic layer is dried over MgSO4
5. concentrationconcentrated