Dimethylformamide → HCID 86757984, compound

Participants

Reaction Steps

0.283 cm3 of oxalyl chloride and then a drop of dimethylformamide are successively added, at a temperature close to 20° C., to a suspension of 0.748 g of 4-(N,N-di-n-propylaminomethylene)benzoic acid monohydrochloride in 20 cm3 of dichloromethane. The reaction medium is kept stirred at a temperature close to 20° C. until the gaseous emission ceases, and then concentrated to dryness under reduced pressure (about 0.5 kPa) at a temperature close to 35° C. The white solid thus obtained is used as a base for the preparation of 4,4′-O,O-di(4-(N,N-di-n-propylaminomethylene)benzoyl)-2-[(1R,2S,3R)(1,2,3,4-tetrahydroxybutyl)]-5-[(2′S, 3′R)(2′,3′,4′-trihydroxybutyl)]pyrazine.

Provenance & Evidence