Ammonium Hydroxide → HCID 9903565, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-(3,3-Dimethyl-ureido)-4-propoxy-thiophene-3-carboxylic acid methyl ester ( ) in ethanol (6 mL) was treated with concentrated ammonium hydroxide (6 mL) in a sealed tube and heated to 40° C. for 5 hours. The mixture was then cooled, evaporated, acidified with a small amount of acetic acid and purified via radial chromatography on a 2 mm plate using hexanes/ethyl acetate (3/1) plus 2% methanol as eluent to afford a white solid (15 mg, 55.3 micromol, 51%) 1H NMR (CDCL3, 400 MHz) 1.03 (t, 3H, J=7.3 Hz), 1.81-1.88 (m, 2H), 3.04 (s, 6H), 3.97 (t, 2H, J=6.6 Hz), 5.33 (broad s, 1H), 5.55 (s, 1H), 7.50 (broad s, 1H), 12.00 (s, 1H).

Provenance & Evidence