HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethylamine → 2-(4-Bromo-1H-pyrazol-1-yl)-N-(2-methoxyethyl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethylamine | HCID 8018 | — |
| Reactant | 4-Bromo-1-(2-chloroethyl)-1H-pyrazole | HCID 51892074 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(4-Bromo-1H-pyrazol-1-yl)-N-(2-methoxyethyl)ethanamine | HCID 62565688 | — |
Reaction Steps
A solution of 2-methoxyethanamine (8.9 mL, 102.06 mmol) and chloride 75 (7.13 g, 34.02 mmol) in DMSO (20 mL) was heated at 60° C. 5 h. The mixture was then cooled to room temperature, diluted with EtOAc, washed with aqueous sodium bicarbonate, water and brine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846927B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-d2b70bd9f5b946e39495ccc7c33c597b |
| Source note | uspto-grants-2014_09 |