反应详情

[Carboxymethyl(4-methoxybenzenesulfonyl)amino]acetic acid (0.5 grams, 1.65 mmol) in acetic anhydride (15 mL) was dissolved in acetic anhydride by gentle warming. The resulting solution was stirred at room temperature overnight. The acetic anhydride was removed by evaporation under vacuum; the residue was dissolved in methylene chloride and morpholine (0.16 mL, 1.82 mmol) was added. The mixture was stirred overnight at room temperature and then concentrated under vacuum. The residue was dissolved in ethyl acetate, washed with 1N hydrochloric acid solution, water and brine, dried over magnesium sulfate and concentrated to afford [(4-methoxybenzenesulfonyl)(2-morpholin-4-yl-2-oxoethyl)amino]acetic acid as an oil, 0.33 grams (54%).

1. customThe acetic anhydride was removed by evaporation under vacuum
2. dissolutionthe residue was dissolved in methylene chloride
3. stirringThe mixture was stirred overnight at room temperature
4. concentrationconcentrated under vacuum
5. dissolutionThe residue was dissolved in ethyl acetate
6. washwashed with 1N hydrochloric acid solution, water and brine
7. dry with materialdried over magnesium sulfate
8. concentrationconcentrated