HCID 18734739, compound → HCID 14054247, compound

HRID 843714Notes

Reaction equation

HRID 843714 reaction equation
[N:1]([CH2:4][C@H:5]([NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[C:6]([O:8][CH2:9][CH3:10])=[O:7])=[N+]=[N-]>C(O)C.[Pd]>[CH2:9]([O:8][C:6](=[O:7])[C@@H:5]([NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:4][NH2:1])[CH3:10]

Participants

4

Reactant 1

HCID 18734739HCID 18734739, compound

Product 1

HCID 14054247HCID 14054247, compoundYield 100.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of ethyl 3-azido-2(S)-(tert-butoxycarbonyl)aminopropionate (0.5 g) and 10% Pd—C (0.1 g, 50% wet) in ethanol (5 ml) was hydrogenated at atmospheric pressure for 1 hour. After the catalyst was removed by filtration, the filtrate was concentrated in vacuo to give 2(S)-(tert-butoxycarbonyl)amino-β-alanine ethyl ester (0.45 g).

Workup

  1. customAfter the catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-c8817645c7b3474399a0c1572795ad66
Source dataset
uspto-grants-2002_04
Patent number
US06380215B1

Reaction notes

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