Sodium Hydroxide → HCID 22611864, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-[l-{2-(1-benzyloxycarbonyl4-piperidyloxy)acetyl}-3-piperidylcarbonyl]-β-alanine methyl ester (1.33 g) in methanol (10 ml), H2O (10 ml) and tetrahydrofuran (10 ml) was added 1N NaOH (8.55 ml) under stirring at 0° C. After stirring at ambient temperature for 3 hours, the mixture was acidified with 10% KHSO4 aqueous solution, and extracted with ethyl acetate. The extract was washed with water and brine, and dried over MgSO4, and evaporated in vacuo to give N-[1-{2-(1-benzyloxycarbonyl-4-piperidyloxy)acetyl}-3-piperidylcarbonyl]-β-alanine (1.22 g) as an oil.

Provenance & Evidence