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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 843793Generated: October 26, 2026

alpha-Methylbenzyl isocyanate → N-(alpha-methylbenzyl)-N'-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)urea

https://huagongshe.com/reaction/843793

Reaction equation

Participants

RoleNameHCIDCharge
Reactantalpha-Methylbenzyl isocyanateHCID 85760—
Reactant3-(1-Methylpiperidin-4-yl)-1h-indol-5-amineHCID 11831220—
ProductN-(alpha-methylbenzyl)-N'-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)ureaHCID 2261151697.3%

Reaction Steps

Beginning with 15.0 mg (0.0655 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 12.51 mg (0.0852 mMol) α-methylbenzyl isocyanate, 24.0 mg (97%) of the title compound were recovered.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06380201B1
Source datasetuspto-grants-2002_04
ORD IDord-bd37bf1e0a0446e7b98977c0a6a007de
Source noteuspto-grants-2002_04