4-Fluorobenzoyl chloride → HCID 21842978, compound

HRID 843806Notes

Reaction equation

HRID 843806 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11]1[CH2:12][CH2:13][N:14]([CH2:17][CH3:18])[CH2:15][CH:16]=1.[F:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1>>[F:19][C:20]1[CH:28]=[CH:27][C:23]([C:24]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][CH:6]=[C:5]3[C:11]2[CH2:12][CH2:13][N:14]([CH2:17][CH3:18])[CH2:15][CH:16]=2)=[O:25])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 22611536HCID 22611536, compound

Product 1

HCID 21842978HCID 21842978, compoundYield 59.2%

Procedure

Beginning with 2.69 gm (11.1 mMol) 5-amino-3-(1-ethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole and 1.45 mL (12.3 mMol) 4-fluorobenzoyl chloride, 2.39 gm (59.0%) of the title compound were recovered as a burnt orange powder.

Sources & evidence

ORD record
ord-cb148f6c09604e4c8b1c8a32f378885a
Source dataset
uspto-grants-2002_04
Patent number
US06380201B1

Reaction notes

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