3-(1-Methylpiperidin-4-yl)-1h-indol-5-amine → HCID 22611578, compound

HRID 843834Notes

Reaction equation

HRID 843834 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH:18]1([C:28](O)=[O:29])[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:21][CH2:20][CH2:19]1>>[CH:18]1([C:28]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][CH:6]=[C:5]3[CH:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)=[O:29])[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amineHCID 125981461,2,3,4-Tetrahydro-1-naphthoic acid

Product 1

HCID 22611578HCID 22611578, compound

Procedure

Beginning with 12.0 mg (0.05 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole with 16.2 mg (0.10 mMol) 1,2,3,4-tetrahydro-1-naphthoic acid at 70° C., 16.2 mg (84%) of the title compound were recovered.

Workup

  1. custom16.2 mg (84%) of the title compound were recovered

Sources & evidence

ORD record
ord-21794c979f6949e1ad37e00f350c49ff
Source dataset
uspto-grants-2002_04
Patent number
US06380201B1

Reaction notes

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