2-Chloro-4-fluorobenzoyl chloride → HCID 54412866, compound

HRID 843934Notes

Reaction equation

HRID 843934 reaction equation
C(O[C:6]([NH:8][C:9]1[CH:10]=[C:11]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17]1[CH2:16][CH2:15][CH:14]([N:22]([CH3:24])[CH3:23])[CH2:13][C:12]2=1)=[O:7])(C)(C)C.[Cl:25][C:26]1[CH:34]=[C:33]([F:35])[CH:32]=[CH:31][C:27]=1C(Cl)=O>>[Cl:25][C:26]1[CH:34]=[C:33]([F:35])[CH:32]=[CH:31][C:27]=1[C:6]([NH:8][C:9]1[CH:10]=[C:11]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17]1[CH2:16][CH2:15][CH:14]([N:22]([CH3:23])[CH3:24])[CH2:13][C:12]2=1)=[O:7]

Participants

3

Reactant 2

HCID 27365462-Chloro-4-fluorobenzoyl chlorideHCID 54055691HCID 54055691, compound

Product 1

HCID 54412866HCID 54412866, compoundYield 94.1%

Procedure

Beginning with 0.081 gm (0.245 mMol) 6-(t-butoxycarbonyl)amino-3-(dimethyl)amino-1,2,3,4-tetrahydro-9H-carbazole and 0.046 gm (0.27 mMol) 2-chloro-4-fluorobenzoyl chloride, 0.089 gm (94%) of the title compound were recovered as a light beige solid.

Sources & evidence

ORD record
ord-5f483c796b1b42b4be809237a1a58f5f
Source dataset
uspto-grants-2002_04
Patent number
US06380201B1

Reaction notes

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