反应详情

To a solution of 0.871 gm (2.98 mMol) 6-benzyloxy-3-amino-1,2,3,4-tetrahydro-9H-carbazole in 200 mL ethanol were added about 2.0 gm Raney Nickel and hydrogen introduced to the reaction mixture under balloon pressure. After stirring for 18 hours at room temperature the balloon was refilled with hydrogen and the reaction stirred an additional 3 days at room temperature. The reaction mixture was filtered and the filtrate concentrated under reduced pressure to give a colorless solid. The residual solid was subjected to silica gel chromatography, eluting with 80:15:5 dichloromethane: methanol:ammonium hydroxide. Fractions shown to contain product were combined and concentrated under reduced pressure to give 0.335 gm (56%) of the title compound.

1. additionintroduced to the reaction mixture under balloon pressure
2. stirringthe reaction stirred an additional 3 days at room temperature
3. filtrationThe reaction mixture was filtered
4. concentrationthe filtrate concentrated under reduced pressure
5. customto give a colorless solid
6. washeluting with 80:15:5 dichloromethane
7. concentrationconcentrated under reduced pressure