HCID 22611224, compound → HCID 54471240, compound

HRID 843941Notes

Reaction equation

HRID 843941 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17]1[CH:16]([NH2:22])[CH2:15][CH:14](CCC3C=CC=CC=3)[CH2:13][C:12]2=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O[C:32]1[CH:33]=[C:34]2[C:42](=[CH:43][CH:44]=1)N[C:40]1CCC(NCCC3C=CC=CC=3)C[C:35]2=1>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:13]1[CH2:14][CH2:15][CH:16]([NH:22][CH2:40][CH2:35][C:34]3[CH:42]=[CH:43][CH:44]=[CH:32][CH:33]=3)[CH2:17][C:12]2=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 22611224HCID 22611224, compoundHCID 22611226HCID 22611226, compound

Product 1

HCID 54471240HCID 54471240, compound

Procedure

Beginning with 0.336 gm (0.85 mMol) 6-benzyloxy-3-(2-phenyleth-1-yl)-amino-1,2,3,4-tetrahydro-9H-carbazole, 0.175 gm (67%) of 6-hydroxy-3-(2-phenylethyl)amino-1,2,3,4-tetrahydro-9H-carbazole were prepared by the procedure described in detail in EXAMPLE B-35. The hydrochloride salt was prepared and crystallized from ethanol/diethyl ether to give the title compound.

Workup

  1. customwere prepared by the procedure
  2. customcrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-4c4ff27f858d4439a4f01e78aa0e8ef4
Source dataset
uspto-grants-2002_04
Patent number
US06380201B1

Reaction notes

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