HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 843985Generated: October 30, 2026
Hydrogen Peroxide → 2-(3-chlorophenoxy)nicotinamide
https://huagongshe.com/reaction/843985
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Reactant | HCID 22612128 | HCID 22612128 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(3-chlorophenoxy)nicotinamide | HCID 1211466 | — |
Reaction Steps
A solution of 2-(3-Chloro-phenoxy)-nicotinonitrile (7.81 grams, 33.9 mmole), 3% hydrogen peroxide (190 ml, 169 mmole) and 50% potassium hydroxide (380 ml, 3.39 mmole) in ethanol (100 ml) was stirred at 70° C. over night. The mixture was concentrated to 250 ml and cooled to 0° C. A solid was isolated by filtration, dissolved in ethyl acetate, dired over magnesium sulfate and concentrated to a white solid (6.51 g). M.P. 225-228° C.; MW 248.67; MS (m/e) 250 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06380218B1 |
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| Source dataset | uspto-grants-2002_04 |
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| ORD ID | ord-96f39733c9594f15b295688aee3311b4 |
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| Source note | uspto-grants-2002_04 |
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