反应详情

温度

220 °C

A mixture of 1-(3-chloro-5-methoxy-phenyl)-ethanone (14.3 g, 0.08 mol.) and pyridine hydrochloride (44.8 g, 0.39 mol.) was heated at 220° C. for 2 hrs. The mixture was poured into water (200 mL) and extracted with ethyl acetate (2×200 mL). The organic extracts were combined, washed with water (40 mL), brine (40 mL) and concentrated to give an oil. Flash Chromatography on Silica Get eluting with ethyl acetate/hexanes (1:1) gave 6.6 g solid. MS (m/e): 170/172 (M+).

1. extractionextracted with ethyl acetate (2×200 mL)
2. washwashed with water (40 mL), brine (40 mL)
3. concentrationconcentrated
4. customto give an oil
5. customFlash Chromatography on Silica Get
6. washeluting with ethyl acetate/hexanes (1:1)